![]() Statistical analysis Continuous data are presented as the mean ± standard deviation. Thus, under these guidelines the choice of CVD risk calculator is important when assessing CVD risk in patients with type 2 diabetes, particularly for the identification of the relatively small proportion of younger people who require statin therapy. The risk engine is available from the Diabetes Trials Unit, Oxford University Centre for Diabetes, Endocrinology, and Metabolism (available from ). The UKPDS Risk Engine is a type 2 diabetes specific risk calculator based on 53,000 patients years of data from the UK. These results suggest that the use of Framingham-derived rather than UKPDS Risk Engine-derived CVD risk estimates would deny about one in 25 patients statin therapy when applying current NICE guidelines. There was no difference between the UKPDS Risk Engine and Framingham classification of women at high risk (p = 0.834). The Framingham CVD equation classified fewer men and people aged <50 years old as high risk (p < 0.0001). More patients were classified as being at high risk by the UKPDS Risk Engine (65%) than by the Framingham CVD equation (63%) (p < 0.0001). The cohort comprised 65% men, 91% whites, 4% Afro-Caribbeans, 5% Asian Indians and 15% current smokers. ![]() The median (interquartile range) diabetes duration was 6 (3-11) years and the HbA(1c) level was 8.0% (7.2-9.0%). Dominics labs at Oxford and Sanger work together as a single group. He holds a joint position as MRC Clinical Research Professor at Oxford University, and as a Principal Investigator at the Wellcome Trust Sanger Institute. Dominic Kwiatkowski is director of the Centre for Genomics and Global Health. The mean (SD) age of the patients was 60.7 (8.6) years, blood pressure 141/83 (17/10) mmHg and the total cholesterol:HDL-cholesterol ratio was 3.9 (1.0). Group Head / PI and Consultant Physician. The 10 year CVD risks were estimated using the UK Prospective Diabetes Study (UKPDS) Risk Engine and the Framingham equation for 4,025 patients enrolled in the Lipids in Diabetes Study who had established type 2 diabetes and LDL-cholesterol <4.1 mmol/l. ![]() The aim of this study was to investigate the impact of using a non-diabetes-specific cardiovascular disease (CVD) risk calculator to determine eligibility for statin therapy according to current UK National Institute for Health and Clinical Excellence (NICE) guidelines for those patients with type 2 diabetes who are at an increased risk of CVD (10 year risk >or=20%). ![]()
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